In the field of cellular metabolism and endurance research, AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) has earned a reputation as a powerful activator of AMP-activated protein kinase (AMPK). QRP Nutrition’s AICAR QRP Nutrition 50mg formulation is designed to meet the highest research standards, delivering exceptional purity and performance for investigators exploring its effects on mitochondrial health, fat metabolism, and endurance.
What is AICAR?
AICAR is a synthetic analog of adenosine monophosphate (AMP) and a direct AMPK activator. AMPK plays a central role in energy homeostasis—it gets activated when cellular energy levels are low, promoting catabolic pathways that generate ATP.
Through AMPK activation, AICAR triggers processes that:
- Enhance fatty acid oxidation
- Increase glucose uptake
- Stimulate mitochondrial biogenesis
- Inhibit protein synthesis and fat storage
Because of these effects, AICAR is widely studied for its potential in metabolic diseases, athletic performance, and age-related disorders.
⚗️ Key Research-Backed Benefits of AICAR
- Endurance Enhancement
In mouse models, AICAR increased running endurance by up to 44% without training, thanks to mitochondrial adaptations. - Fat Loss and Metabolic Optimization
Promotes fatty acid oxidation while improving insulin sensitivity, making it valuable for obesity and diabetes research. - Neuroprotective Potential
Studies suggest AMPK activation via AICAR may support brain energy metabolism and offer protection in neurodegenerative models. - Muscle Preservation
May help prevent muscle wasting by regulating autophagy and muscle energy balance during caloric deficits.
Product Details: QRP Nutrition AICAR 50mg
- Dosage: 50 mg per vial (lyophilized powder)
- Purity: >99% HPLC verified
- Form: Research-grade lyophilized peptide for reconstitution
- Manufacturing: Produced in GMP-certified laboratories with full COA and third-party testing
Common Research Protocols (for authorized use only)
⚠️ Disclaimer: AICAR is a research chemical. It is not approved for human consumption outside experimental or laboratory environments.
- Reconstitution:
Mix 50 mg with 2 mL of sterile bacteriostatic water to create a 25 mg/mL solution. - Typical Research Dosages:
– Range from 10–50 mg daily depending on subject and study design
– Often studied over 4–6 week cycles to observe mitochondrial and endurance-related effects - Administration Routes:
– Intraperitoneal or subcutaneous in animal models
– Occasionally explored orally in non-human primates (with limited bioavailability)
Mechanism of Action: AMPK Activation
By mimicking AMP, AICAR binds directly to the γ subunit of AMPK, activating the enzyme without needing a drop in cellular energy levels. This “tricks” the cell into initiating energy-conserving and ATP-generating processes—making it an exceptional candidate for endurance and metabolic stress research.
⚠️ Potential Side Effects (in research settings)
- Temporary fatigue or lethargy during initial use (linked to energy redirection)
- Possible hypoglycemia due to increased glucose uptake
- Long-term effects under investigation—caution advised in extended protocols
✅ Why Choose QRP Nutrition?
- Ultra-pure formulations for reliable and reproducible data
- Batch tracking and documentation included with each order
- Discreet global shipping to approved laboratories and research facilities
- Dedicated support team to assist with study design and compound handling
Conclusion
QRP Nutrition’s AICAR 50mg delivers a potent and research-validated compound for scientists exploring the boundaries of endurance, metabolic flexibility, and mitochondrial health. As one of the most powerful AMPK activators available, AICAR continues to show promise across a wide range of experimental applications.
For laboratory research use only. Not for human or veterinary use without approval.
Explore more compounds and metabolic research solutions at QRP Nutrition’s official site.